Norfloxacin penetration into human renal and prostatic tissues

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Norfloxacin penetration into human renal and prostatic tissues.

Concurrent norfloxacin concentrations in serum, kidney, and prostatic tissue were determined in 14 patients. Mean ratios of norfloxacin concentration in tissue over concentration in serum were 6.6 +/- 2.8 for the kidney and 1.7 +/- 0.2 for the prostate samples. The levels were above the MICs of most urinary pathogens.

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Antibiotic penetration into lung tissues

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Antibiotic penetration into lung tissues

Effective antibiotic treatment for lung infections requires an amount of drug at the site of infection sufficient to achieve or exceed the minimum inhibitory concentration (MIC) for that antibiotic against the pathogen. Recent developments in methodology have enabled concentrations of many antibiotics to be measured in small samples of tissue. The two main assay techniques are either a microbio...

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ژورنال

عنوان ژورنال: Antimicrobial Agents and Chemotherapy

سال: 1985

ISSN: 0066-4804,1098-6596

DOI: 10.1128/aac.28.2.349